Talk:Androgen
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Latest comment: 6 months ago by Pabnau in topic Relative potency
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Based on other sources, I suspect the listed numbers for Androstenediol-Androsterone are not percentages, so they are 100x smaller than they should be. Unfortunately, I don’t have access the cited source, so I can’t confirm, and there’s a lot of variation between different sources. The source is 50 years old anyways, so we probably should find the more up-to-date numbers. I’ll add a [better source] tag
| Androgen | Potency (%) |
|---|---|
| Testosterone | 40 |
| 5α-Dihydrotestosterone (DHT) | 100 |
| Androstenediol | .0008 |
| Androstenedione | .04 |
| Dehydroepiandrosterone | .02 |
| Androsterone | .06 |
Pabnau (talk) 18:46, 9 February 2026 (UTC) Reply
- On review of the edit history, it seems that people are just changing the numbers willy nilly, presumably based on un-cited sources, so this is probably a deeper problem. I’m going to see if I can find some accessible authoritative sources, and we may need to change these numbers to ranges to account for disagreement between sources Pabnau (talk) 18:57, 9 February 2026 (UTC) Reply
- This source appears to free access and relatively recent, and it discusses some of the differences in results compared to other papers. I suspect another potential source of disagreement is due to the fact that many androgens get converted to more potent androgens in the body, so the pharmaceutical potency may be different from the receptor affinity. I’ll modify the table for this source, and add in some qualifications. For reference, for the table, Dehydroepiandrosterone=5,6-Didehydroisoandrosterone, androstenodione=4-androstenodione.Pabnau (talk) 20:23, 9 February 2026 (UTC) Reply
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