E-site
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The E-site is the third and final binding site for t-RNA in the ribosome during translation, a part of protein synthesis.[1] The "E" stands for exit, and is accompanied by the P-site (for peptidyl) which is the second binding site, and the A-site (aminoacyl), which is the first binding site. It is involved in cellular processes.[2]
References
- ^ Chen, C.; Stevens, B.; Kaur, J.; Smilansky, Z.; Cooperman, B. S.; Goldman, Y. E. (2011年10月03日). "Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis". Proceedings of the National Academy of Sciences. 108 (41): 16980–16985. Bibcode:2011PNAS..10816980C. doi:10.1073/pnas.1106999108 . ISSN 0027-8424. PMC 3193197 . PMID 21969541.
- ^ Kirillov, S.V.; Makarov, E.M.; Semenkov, Yu.P. (27 June 1983). "Quantitative study of interaction of deacylated tRNA with Escherichia coli ribosomes: Role of 50 S subunits in formation of the E site". FEBS Letters. 157 (1): 91–94. doi:10.1016/0014-5793(83)81122-3.
Further reading
- Wilson, D. N.; Nierhaus, K. H. (December 2006). "The E-site story: the importance of maintaining two tRNAs on the ribosome during protein synthesis". Cellular and Molecular Life Sciences. 63 (23): 2725–2737. doi:10.1007/s00018-006-6125-4. PMC 11136154 .
- Nierhaus, K (August 2006). "Decoding errors and the involvement of the E-site". Biochimie. 88 (8): 1013–1019. doi:10.1016/j.biochi.200602009.
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