Disulergine
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Pharmaceutical compound
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| Other names | CH-29717; CH 29-717; Sulergine; N,N-Dimethyl-N'-(6-methylergoline-8α-yl)sulfamide |
| Drug class | Dopamine agonist; Prolactin inhibitor |
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| Formula | C17H24N4O2S |
| Molar mass | 348.47g·mol−1 |
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Disulergine (INN Tooltip International Nonproprietary Name; developmental code names CH-29717 or CH 29-717) is a dopamine agonist of the ergoline family described as a prolactin inhibitor which was never marketed.[1] [2] [3] [4] It is known to be a metabolite of mesulergine.[5] [6] The drug was first described in the literature by 1976.[1] [3]
See also
References
- 1 2 Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. ISBN 978-1-4757-2085-3 . Retrieved 30 June 2025.
- ↑ Symposium NN (1986). The Neurobiology of Dopamine Systems. Manchester University Press. ISBN 978-0-7190-1799-5 . Retrieved 30 June 2025.
- 1 2 Flückiger E, Briner U, Doepfner W, Kovacs E, Marbach P, Wagner HR (October 1978). "Prolactin secretion inhibition by a new 8alpha-amino-ergoline, CH 29-171". Experientia. 34 (10): 1330–1332. doi:10.1007/BF01981452. PMID 570121.
- ↑ Markó M (June 1984). "Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines". European Journal of Pharmacology. 101 (3–4): 263–266. doi:10.1016/0014-2999(84)90167-5. PMID 6468500.
- ↑ Baas H, Schneider E, Fischer PA, Japp G (1985). "Mesulergine and bromocriptine in long-term treatment of advanced parkinsonism". Journal of Neural Transmission. 64 (1): 45–54. doi:10.1007/BF01259344. PMID 4067602.
- ↑ Enz A, Donatsch P, Nordmann R (1984). "Dopaminergic properties of mesulergine (CU 32-085) and its metabolites". Journal of Neural Transmission. 60 (3–4): 225–238. doi:10.1007/BF01249095. PMID 6527137.
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