Veterinary Pharmacology and Therapeutics, Ninth Edition is the long awaited update of the gold-standard reference on veterinary pharmacology and therapeutics. The field of veterinary pharmacology continues to evolve and expand and this new edition has been revised to reflect changes in the field. Veterinary Pharmacology and Therapeutics, Ninth Edition is thoroughly revised, updated, and expanded to meet the needs of today s veterinarians, veterinary students, and animal health researchers.

Contributors ix Preface xv Section 1. Principles of Pharmacology 3 1. Veterinary Pharmacology: An Introduction to the Discipline 5 Jim E. Riviere and Mark G. Papich 2. Absorption, Distribution, Metabolism, and Elimination 11 Jim E. Riviere 3. Pharmacokinetics 47Jim E. Riviere 4. Mechanisms of Drug Action and Pharmacokinetics/Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine 75Pierre-Louis Toutain Section 2. Drugs Acting on the Autonomic Nervous System 99 5. Introduction to Neurohumoral Transmission and the Autonomic Nervous System 101H. Richard Adams. 6. Adrenergic Agonists and Antagonists 125H. Richard Adams. 7. Cholinergic Pharmacology: Autonomic Drugs 157H. Richard Adams Section 3. Anesthetics and Analgesics 181 8. Introduction to Drugs Acting on the Central Nervous System and Principles of Anesthesiology 183 Peter J. Pascoe and Eugene P. Steffey 9. Neuromuscular Blocking Agents 211H. Richard Adams 10. Inhalation Anesthetics 229 Eugene P. Steffey 11. Injectable Anesthetic Agents 265 Lysa P. Posner and Patrick Burns 12. Opioid Analgesic Drugs 301 Butch KuKanich and Mark G. Papich 13. Sedative Agents: Tranquilizers, Alpha-2 Agonists, and Related Agents 337 Lysa P. Posner and Patrick Burns 14. Local Anesthetics 381 Alistair I. Webb and Luisito S. Pablo 15. Euthanizing Agents 401 Alistair I. Webb Section 4. Autacoids and Anti-inflammatory Drugs 409 16. Histamine, Serotonin, and Their Antagonists 411 H. Richard Adams 17. Peptides: Angiotensin and Kinins 429H. Richard Adams 18. Prostaglandins, Related Factors, and Cytokines 439H. Richard Adams 19. Analgesic, Anti-inflammatory, Antipyretic Drugs 457 Peter Lees 20. Anticonvulsant Drugs 493Mark G. Papich 21. Drugs Affecting Animal Behavior 509Barbara L. Sherman and Mark G. Papich Section 5. Drugs Acting on the Cardiovascular System 539 22. Digitalis, Positive Inotropes, and Vasodilators 541Matthew W. Miller and H. Richard Adams 23. Antiarrhythmic Agents 575 Matthew W. Miller and H. Richard Adams Section 6. Drugs Affecting Renal Function and Fluid-Electrolyte Balance 603 24. Principles of Acid-Base Balance: Fluid and Electrolyte Therapy 605Deborah T. Kochevar and Maya M. Scott 25. Diuretics 647 Deborah T. Kochevar Section 7. Drugs Acting on Blood and Blood Elements 671 26. Hemostatic and Anticoagulant Drugs 673H. Richard Adams Section 8. Endocrine Pharmacology 691 27. Hypothalamic and Pituitary Hormones 693Srujana Rayalam, Margarethe Hoenig, and Duncan Ferguson 28. Hormones Affecting Reproduction 717Doodipla S. Reddy and John E. Gadsby 29. Thyroid Hormones and Antithyroid Drugs 735 Duncan C. Ferguson 30. Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs 771 Duncan C. Ferguson, Levent Dirikolu, and Margarethe Hoenig 31. Drugs Influencing Glucose Metabolism 803Margarethe Hoenig Section 9. Chemotherapy of Microbial Diseases 817 32. Antiseptics and Disinfectants 819 Mark C. Heit and Jim E. Riviere 33. Sulfonamides and Potentiated Sulfonamides 835 Mark G. Papich and Jim E. Riviere 34. -Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs 865Mark G. Papich and Jim E. Riviere 35. Tetracycline Antibiotics 895 Mark G. Papich and Jim E. Riviere 36. Aminoglycoside Antibiotics 915 Mark G. Papich and Jim E. Riviere 37. Chloramphenicol and Derivatives, Macrolides, Lincosamides, and Miscellaneous Antimicrobials 945 Mark G. Papich and Jim E. Riviere 38. Fluoroquinolone Antimicrobial Drugs 983Mark G. Papich and Jim E. Riviere 39. Antifungal and Antiviral Drugs 1013Jennifer L. Davis, Mark G. Papich, and Mark C. Heit Section 10. Chemotherapy of Parasitic Diseases 1051 40. Antinematodal Drugs 1053 Carlos E. Lanusse, Luis I. Alvarez, Juan M. Sallovitz, Maria L. Mottier, and Sergio F. Sanchez Bruni 41. Anticestodal and Antitrematodal Drugs 1095Carlos E. Lanusse, Guillermo L. Virkel, and Luis I. Alvarez 42. Macrocyclic Lactones: Endectocide Compounds 1119Carlos E. Lanusse, Adrian L. Lifschitz, and Fernanda A. Imperiale 43. Antiprotozoan Drugs 1145 Jennifer L. Davis and Jody L. Gookin 44. Ectoparasiticides 1181 Ronald E. Baynes Section 11. Specialty Areas of Pharmacology 1203 45. Chemotherapy of Neoplastic Diseases 1205Gordon L. Coppoc 46. Immunosuppressive Drugs and Cyclosporine 1233 Mark G. Papich 47. Drugs Affecting Gastrointestinal Function 1247Mark G. Papich 48. Dermatopharmacology: Drugs Acting Locally on the Skin 1273 Jim E. Riviere 49. Drugs that Affect the Respiratory System 1295Mark G. Papich 50. Pharmacogenomics 1313 Katrina L. Mealey 51. Therapeutic Drug Monitoring 1323Mark G. Papich 52. Considerations for Treating Minor Food-Producing Animals with Veterinary Pharmaceuticals 1331 Lisa A. Tell, Margaret Oeller, and Arthur L. Craigmill 53. Zoological Pharmacology 1343Robert P. Hunter Section 12. Regulatory Considerations. 1353 54. Legal Control of Veterinary Drugs 1355Stephen F. Sundlof 55. Drug Approval Process 1365 Marilyn Martinez, Melanie Berson, Bernadette Dunham, Joan Gotthardt, and Laura Hungerford 56. Veterinary Pharmacy 1407 Gigi Davidson 57. Regulation of Drug and Medication Use in Performance Animals 1419 Cynthia A. Cole and Keith Zientek 58. Adverse Drug Reactions 1431 Victoria Hampshire and Margarita A. Brown 59. Dosage Forms and Veterinary Feed Directives 1439 Jim E. Riviere and Geof W. Smith 60. USP s Role in Veterinary Pharmacology and Evidence-Based Information 1445Cory Langston, Stefan Schuber, and Ian R. DeVeau 61. Chemical Residues in Tissues of Food Animals 1453Jim E. Riviere and Stephen F. Sundlof Index 1463