内容説明
Biochemistry and Molecular Biology is the perfect resource for any student without previous experience in the subject who needs to know its key principles and concepts - whether they are studying biology or biochemistry, biomedical science or nutrition. The book blends the fundamentals of molecular biology and biochemistry with the latest technological advances, including mass spectrometry, RNA interference, X-ray synchrotron radiation, the medical applications of single nucleotide polymorphisms, the development of pluripotent cells with stem cell potential, and the use of protein and DNA databases and their application to the study of disease-causing genes. It gives a contemporary, intellectually stimulating depiction of the field, while always maintaining a wonderful clarity, enriched by carefully layered explanations and vivid illustrations. Its scope, size and presentation make Biochemistry and Molecular Biology the ideal companion as you explore the subject for the first time.Online Resource Centre: The Online Resource Centre features: For registered adopters of the book: * Figures from the book available to download; * A new test bank of questions, with feedback keyed to the book, for use in formative and summative assessment For students: * A library of weblinks cited in the text; * A hyperlinked bibliography of literature articles cited in the text; * An extensive bank of multiple-choice questions for self-directed learning
目次
- PART 1 BASIC CONCEPTS OF LIFE
- 1. The basic molecular themes of life
- 2. Cells and viruses
- 3. Energy considerations in biochemistry
- PART 2 STRUCTURE AND FUNCTION OF PROTEINS AND MEMBRANES
- 4. The structure of proteins
- 5. Methods in protein investigation
- 6. Enzymes
- 7. The cell membrane and membrane proteins
- 8. Muscle contraction, the cytoskeleton, and molecular motors
- PART 3 METABOLISM
- 9. Food digestion, absorption, distribution to the tissues and appetite control
- 10. Mechanisms of transport, storage and mobilisation of dietary components
- 11. Principles of energy release from food
- 12. Glycolysis, the citric acid cycle, and the electron transport system
- 13. Energy release from fat
- 14. The synthesis of fat and related compounds
- 15. Synthesis of glucose (gluconeogenesis)
- 16. Strategies for metabolic control and their applications to carbohydrate and fat metabolism
- 17. Why should there be an alternative pathway of glucose oxidation? The pentose phosphate pathway
- 18. Raising electrons of water back up the energy scale - photosynthesis
- 19. Amino acid metabolism
- 20. Nucleotide synthesis and metabolism
- PART 4 INFORMATION STORAGE AND UTILISATION
- 21. The genome
- 22. DNA synthesis, repair and recombination
- 23. Gene transcription and control
- 24. Protein synthesis and controlled protein breakdown
- 25. The RNA world - RNA microgenes and RNA interference
- 26. Protein sorting and delivery
- 27. Cell signalling
- 28. Manipulating DNA and genes
- PART 5 MOLECULAR BIOLOGY IN HEALTH AND DISEASE
- 29. Special topics: blood clotting, xenobiotic metabolism, reactive oxygen species
- 30. The immune system
- 31. The cell cycle and its control
- 32. Apoptosis
- 33. Cancer
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