内容説明
This volume considers the transport of molecules, large and small, across the membranes of prokaryotic and eukaryotic microbial cells. A diverse range of related phenomena are covered, but the unifying themes are the signal peptides that target proteins to particular destinations, and the role of chaperonins. Topics covered include: secretion of proteins out of the bacterial cell by Type I, II and III mechanisms, including the newly recognised bacterial signal recognition pathway in Type II; passage across internal membranes of eukaryotic proteins, whether destined for secretion or en route to internal organelles such as chloroplasts and peroxisomes; how bacteria obtain the energy required for solute uptake, the role of phosphorylation, and evolutionary relationships of some of the proteins involved; and efflux pumps for toxic substances in bacterial, animal and plant cells.
目次
- Preface
- 1. Overview: transport of molecules across microbial membranes - a sticky business to get to grips with J. K. Broome-Smith and C. Mitsopoulos
- 2. Multidrug resistance efflux K. Lewis
- 3. Regulation of solute accumulation in bacteria and its physiological significance B. Poolman
- 4. Arsenic transport systems from Escherichia coli to humans H. Bhattacharjee, M. Ghosh, R. Mukhopadhyay and B. P. Rosen
- 5. Type II protein secretion: the main terminal branch of the general secretory pathway A. Filloux
- 6. Type III secretion and the pathogenesis of Yersinia infections D. M. Anderson, L. W. Cheng, V. T. Lee, S. Masmanian, K. Ramamurthi, C. Tam and O. Schneewind
- 7. Assembly of bacterial adhesins across the outer membrane via the chaperone-usher pathway G. E. Soto and S. J. Hultgren
- 8. DNA uptake by transformable bacteria S. A. Lacks
- 9. Escherichia coli signal recognition particle - a historical perspective Q. A. Valent, E. N. S. O'Gorman, P. Scotti, J. Luirink and S. High
- 10. Protein translocation into the endoplasmic reticulum B. P. Young, J. K. Brownsword and C. J. Stirling
- 11. Peroxisome biogenesis E. Lopez-Huertas and A. Baker
- 12. Transport of proteins into and across the thylakoid membrane C. Robinson, W. Edwards, P. J. Hynds and C. Tissier
- 13. Evolutionary origins of transmembrane transport systems M. H. Saier Jr and T.-T. Tseng
- Index.
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