Description
Interleukins research is a rapidly moving field of science that has reached a stage where a comprehensive volume is required. The history into the Interleukins dates back several decades with the pioneering work on endogenous pyrogen. This book deals with the numerous 'factors' of diverse biological activities identical to IL-1, and with the cloning of the genes for IL-1 and its receptor. Also covered is the growing evidence of the critical role played by IL-1 as an inflammatory mediator in a variety of disease states and the mounting hope that its pharmacological manipulation could bring great clinical benefits. This volume is a detailed survey of current findings and conveys the sense of excitement and promise surrounding the field of Interleukins research.
Table of Contents
List of Contributors. Preface. SECTION A: Introduction. Chapter 1 Fever: historical aspects (6 papers) (E. Atkins). Chapter 2 Was the original endogenous pyrogen interleukin-1 (1 paper) (C. A. Dinarello). SECTION B: Biochemistry of interleukin-1 . Chapter 3 Cloning and expression of interleukin-1 (7 papers) (U. Gubler, Anne O. Chua, D.K. Lugg), Chapter 4 Differential gene expression, synthesis, processing and release of interleukin-1alpha and interleukin-1beta (5 papers) (Y. Kobayashi, K. Matsushima, J. Oppenheim), Chapter 5 The interleukin-1 receptor and post-receptor events (Introduction) (S.K. Dower, S. Gillis and J.E. Simms), Chapter 6 Assay of Interleukin-1 (3 papers) (J.H. Gearing and R. Thorpe), Chapter 7 Mechanisms and mediators in inflammation (8 papers) (G.A. Higgs), Chapter 8 The role of interleukin-1 in the immune response (4 papers), (K. Muegge and S.K. Durum), Chapter 9 Interleukin-1 and the vascular endothelial cell in inflammation (6 papers) (D.O. Haskard), Chapter 10 Interleukin-1 and connective tissue (6 papers) (J. Saklatvala), Chapter 11 Regulatory interactions between interleukin-1, tumor necrosis factor, and other inflammatory mediators (3 papers) (W.E. Scales and S.L. Kunkel). SECTION C: Interleukin-1 and systematic inflammation . Chapter 12 Fever (10 papers) (C.A. Dinarello), Chapter 13 Acute phase proteins (11 papers), Chapter 14 Inflammatory activities of locally or systematically administered interleukin-1 (4 papers) (R. Pettipher and B. Henderson), Chapter 15 Neuroendocrine interactions with interleukin-1 in inflammation (5 papers) (H. Nakamura) Chapter 16 Interleukin-1 in inflammatory joint disease (3 papers) (G. Duff), Chapter 17 Interleukin-1 in dematologic disease (3 papers) (D.N. Saunder), Chapter 18 Oscular inflammation (6 papers) (P. Bhattacherjee and P.S. Kulkarni). SECTION D: Pharmacological manipulation of interleukin-1 . Chapter 19 (4 papers) (J-M Dayer and P. Seckinger), Chapter 20 Pharmacological manipulation of interleukin-1 synthesis, secretion or action (5 papers) (J.A. Schmidt, J. Rhodes and R. Bomford). Subject Index. Elsevier Imprint
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