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i also ran into the problem of cyclic dependencies. i know if i would
call gc.collect() the problem would be solved, but calling gc.collect()
takes a long time. 
the problem is the cyclic dependency with
r.recv=r.read
i have fixed it localy by wrapping the addinfourl into a new class (i
called it addinfourlFixCyclRef) and overloading the close method, and
within the close method set the recv to none again.
class addinfourlFixCyclRef(addinfourl):
 def close(self):
 if self.fp is not None and hasattr(self.fp, "_sock"):
 self.fp._sock.recv = None
 addinfourl.close(self)
....
 r.recv = r.read
 fp = socket._fileobject(r, close=True)
 resp = addinfourlFixCyclRef(fp, r.msg, req.get_full_url())
and when i call .close() from the response it just works. Unluckily i
had to patch even more in case there is an exception called.
For the whole fix see the attachment