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Basically, time.mktime calls time and localtime, and then overwrites
those results. Removing these unnecessary calls results in a fairly
noticeable speedup, lower double-digit percentile improvements for
applications that do time parsing, for example.
The patch below is for 2.5, but should apply to more recent versions.
diff --git a/Modules/timemodule.c b/Modules/timemodule.c
index be02ec2..dad235a 100644
--- a/Modules/timemodule.c
+++ b/Modules/timemodule.c
@@ -599,8 +599,6 @@ time_mktime(PyObject *self, PyObject *tup)
 {
 struct tm buf;
 time_t tt;
- tt = time(&tt);
- buf = *localtime(&tt);
 if (!gettmarg(tup, &buf))
 return NULL;
 tt = mktime(&buf);