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This is similar to bpo-44860, but in the other direction:
 $ docker run -it --rm -h=p fedora:34 bash
 ...
 [root@p /]# yum install python3 -y
 ...
 [root@p /]# type python3
 python3 is hashed (/usr/bin/python3)
 [root@p /]# python3 -V
 Python 3.9.6
 [root@p /]# python3.9 -q
 >>> from distutils.command.install import install
 >>> from distutils.dist import Distribution
 >>> c = install(Distribution())
 >>> c.home = '/foo'
 >>> c.finalize_options()
 >>> c.install_platlib
 '/foo/lib64/python'
 >>> import sysconfig
 >>> sysconfig.get_path('platlib', 'posix_home', vars={'home': '/root'})
 '/foo/lib/python'
sysconfig’s scheme should use `{platlib}` instead of hardcoding 'lib'.
Note that on Python 3.10+ the platlib values from distutils and sysconfig do match (since the distutils scheme is automatically generated from sysconfig), but the issue remains; sysconfig’s scheme should likely include `{platlib}` (adding Victor and Miro to confirm this).