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Instead of using cache, maybe better to use mutable default argument?
For example:
def make_row_factory(cls_factory, **kw):
 def row_factory(cursor, row, cls=[None]):
 rf = cls[0]
 if rf is None:
 fields = [col[0] for col in cursor.description]
 cls[0] = cls_factory("Row", fields, **kw)
 return cls[0](*row)
 return rf(*row)
 return row_factory
namedtuple_row_factory = make_row_factory(namedtuple)
Seem it should add less overhead.