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What about a new PyModuleDef_Slot function?
```
static int my_can_create(/*need any arg??, InterpreterState, etc?*/) {
 if (test_global_condition()) {
 return -1; //Don't allow creation
 }
 return 0; //Allow creation
};
static PyModuleDef_Slot signal_slots[] = {
 {Py_mod_exec, my_exec},
 {Py_mod_can_create, my_can_create},
 {0,0}
};
```