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The SIGINT event gets created when the _signal extension module is imported. Until then, _PyOS_SigintEvent() returns NULL. But currently all code that calls _PyOS_SigintEvent() assumes it returns a valid handle. This has to be fixed to support Py_InitializeEx(0). 
For example, pysleep could call WinAPI Sleep on the main thread if the interrupt event isn't configured:
 ul_millis = (unsigned long)millisecs;
 hInterruptEvent = _PyOS_SigintEvent();
 if (ul_millis == 0 || !hInterruptEvent || !_PyOS_IsMainThread()) {
 Py_BEGIN_ALLOW_THREADS
 Sleep(ul_millis);
 Py_END_ALLOW_THREADS
 break;
 }