homepage

It looks safe to remove this feature.
I failed to find any recent user of _PyThreadState_GetFrame.
Moreover, _PyRuntime.getframe and _PyThreadState_GetFrame have been moved to the internal C API in Python 3.7. This C API was not accessible by third-party projects in Python 3.7. The internal C API can only be used by third-party projects since Python 3.8 and it's tricky to use it... on purpose. I don't recall any complain about _PyThreadState_GetFrame becoming inaccessible.
--
I searched for "_PyThreadState_GetFrame" in C code on GitHub. I only found copies of Python/pystate.c files in the first 10 pages of search results, with one exception. I found one file:
https://github.com/Mistobaan/pdb-clone/blob/517f6d19902b64395b4c7218cbbbecfa5a1de607/lib/pdb_clone/_pdbhandler-py27.c
It's an old (latest commit on Mar 31, 2015) debugger project written by Xavier de Gaye.
It seems like the following flavor is more recent (latest commit on Apr 20, 2019):
https://github.com/corpusops/pdbclone/
Note: the project contains 4 .c files, but only _pdbhandler-py27.c uses _PyThreadState_GetFrame: _pdbhandler-py3.c which is for Python 3 doesn't use _PyThreadState_GetFrame. But Python 2.7 reached its end of life, it's no longer supported.
Copy of the code:
 /* Disable the Python 2 restricted mode in the subinterpreter (see
 * PyEval_GetRestricted()) that prevents linecache to open the source
 * files and prevents attribute access. */
 saved_globals = mainstate->frame->f_globals;
 saved_locals = mainstate->frame->f_locals;
 saved_tstate_getframe = _PyThreadState_GetFrame;
 mainstate->frame->f_globals = globals;
 mainstate->frame->f_locals = locals;
 _PyThreadState_GetFrame = threadstate_getframe;
 pdbhandler_tstate = mainstate;
So _PyThreadState_GetFrame was used to "disable the Python 2 restricted mode", but this mode has been removed from Python 3.