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INADA-san wrote PR 13787 to disable opcache when Python is compiled in debug mode. Pablo and me approved the change, so I merged it.
Pablo wrote a more robust solution, PR 13789, to disable opcache only in regrtest, to look for memory leaks. But INADA-san had a good argument against this approach:
https://github.com/python/cpython/pull/13789#issuecomment-498449735
"The code object will be optimized only when ++co->co_opcache_flag == opcacheminruns. So decreasing min_runs by _setopcacheminruns()will cause some hot codes will be not optimized forever. I don't want to expose such switch."
I would prefer to keep this issue until a long term approach is designed.