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I tested fontforge. It became clear to me that the fontforge must be able to call Py_Initialize() and only later call Py_Main(). fontforge calls Py_Initialize() and then uses the Python API:
/* This is called to start up the embedded python interpreter */
void FontForge_InitializeEmbeddedPython(void) {
 // static int python_initialized is declared above.
 if ( python_initialized )
	return;
 SetPythonProgramName("fontforge");
 RegisterAllPyModules();
 Py_Initialize();
 python_initialized = 1;
 /* The embedded python interpreter is now functionally
 * "running". We can modify it to our needs.
 */
 CreateAllPyModules();
 InitializePythonMainNamespace();
}
Py_Main() is called after FontForge_InitializeEmbeddedPython().
To be clear, Py_Main() must be fixed in Python 3.7 to apply properly the new configuration, or *at least* define sys.argv.