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New opcodes in PR 5071 look interesting, but I think it is better to leave this experiment for a separate issue.
Complexities of PRs (ignoring tests, documentation, and generated files):
PR 4682:
 Include/opcode.h | 12 +-
 Lib/opcode.py | 21 +-
 Objects/frameobject.c | 241 ++++++++-----
 Objects/genobject.c | 10 +-
 Python/ceval.c | 426 +++++++++++------------
 Python/compile.c | 884 +++++++++++++++++++++++++++++++++---------------
 Python/peephole.c | 18 +-
 7 files changed, 979 insertions(+), 633 deletions(-)
PR 5006:
 Include/opcode.h | 8 +-
 Lib/opcode.py | 11 +-
 Objects/frameobject.c | 203 ++++++++-------------
 Objects/genobject.c | 10 +-
 Python/ceval.c | 344 ++++++++++++++++-------------------
 Python/compile.c | 474 +++++++++++++++++++++++++++++-------------------
 Python/peephole.c | 33 ++--
 7 files changed, 561 insertions(+), 522 deletions(-)
PR 5071:
 Include/frameobject.h | 5 +-
 Include/opcode.h | 18 +-
 Lib/opcode.py | 25 +-
 Objects/frameobject.c | 224 ++++++---------
 Objects/genobject.c | 10 +-
 Python/ceval.c | 507 ++++++++++++---------------------
 Python/compile.c | 681 +++++++++++++++++++++++++++++++-------------
 Python/peephole.c | 49 +---
 Python/wordcode_helpers.h | 33 ++-
 9 files changed, 827 insertions(+), 725 deletions(-)
PR 4682: +4 opcodes, -4 opcodes, and changed numerical values of 2 opcodes
PR 5006: +4 opcodes, -4 opcodes
PR 5071: +8 opcodes, -8 opcodes, and changed numerical value of 1 opcode
It looks to me that PR 5006 has the lowest complexity and is the most easy for reviewing.
I'm working on it since taking Antoine's PR 5 months ago.