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The following expression produces 127MB in constants in `co_consts` due to two 63.5MB integer objects produced when folding:
 ((200*200 - 2) & ((1 << 500000000) - 1)) + ((200*200 - 2) >> 500000000)
The optimizer already does not store optimized *sequences* of more than 20 elements to avoid making bytecode files too large:
 If the new constant is a sequence, only folds when the size
 is below a threshold value. That keeps pyc files from
 becoming large in the presence of code like: (None,)*1000.
Perhaps the same should be extended to number objects?
Context: https://stackoverflow.com/questions/43823807/why-does-using-arguments-make-this-function-so-much-slower