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The issue #27128 added _PyObject_FastCall() to avoid the creation of temporary tuples when calling functions.
I propose to add a new METH_FASTCALL calling convention. The example using METH_VARARGS | METH_KEYWORDS:
 PyObject* func(DirEntry *self, PyObject *args, PyObject *kwargs)
becomes:
 PyObject* func(DirEntry *self, PyObject **args, int nargs, PyObject *kwargs)
Using METH_VARARGS, args is a Python tuple. Using METH_FASTCALL, args is a C array of PyObject*, and there is a second nargs parameter.
Later, Argument Clinic will be modified to *generate* code using the new METH_FASTCALL calling convention. Code written with Argument Clinic will only need to be updated by Argument Clinic to get the new faster calling convention (avoid the creation of a temporary tuple for positional arguments).
This issue depends on the issue #27809 "_PyObject_FastCall(): add support for keyword arguments". I will wait until this dependency is implemented, before working on the implementation of this part.
For a full implementation, see my first attempt in the issue #26814. I will extract the code from this branch to write a new patch.