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I am using OSX 10.10.5 (14F27) and Python 3.5. Python 3.5 was installed via brew.
When greenlet is installed inside virtualenv using py3.5 header files are
missing inside /path/to/venv/include/python3.5m. As a result uwsgi is unable to build with asyncio support
~ brew info python3
python3: stable 3.5.0 (bottled), HEAD
Interpreted, interactive, object-oriented programming language
https://www.python.org/
/usr/local/Cellar/python3/3.4.3 (4721 files, 82M)
Poured from bottle
/usr/local/Cellar/python3/3.4.3_2 (5948 files, 98M)
Built from source
/usr/local/Cellar/python3/3.5.0 (3573 files, 61M) *
Poured from bottle
From: https://github.com/Homebrew/homebrew/blob/master/Library/Formula/python3.rb
==> Dependencies
Build: xz , pkg-config 
Required: openssl 
Recommended: readline , sqlite , gdbm , xz 
Optional: homebrew/dupes/tcl-tk
Steps to reproduce
------------------
1. Create a venv
$/tmp python3.5 -m virtualenv venv_bug
2. Install greenlet
$/tmp . venv_bug/bin/activate
(venv_bug)$/tmp pip install greenlet
Collecting greenlet
 Using cached greenlet-0.4.9.tar.gz
Building wheels for collected packages: greenlet
 Running setup.py bdist_wheel for greenlet
 Complete output from command /private/tmp/venv_bug/bin/python3.5 -c "import setuptools;__file__='/private/var/folders/xk/8lhz2_j91_3758cc65stj5z40000gn/T/pip-build-sxtdlufe/greenlet/setup.py';exec(compile(open(__file__).read().replace('\r\n', '\n'), __file__, 'exec'))" bdist_wheel -d /var/folders/xk/8lhz2_j91_3758cc65stj5z40000gn/T/tmpf6g8rwt_pip-wheel-:
 running bdist_wheel
 running build
 running build_ext
 building 'greenlet' extension
 creating build
 creating build/temp.macosx-10.10-x86_64-3.5
 clang -Wno-unused-result -Wsign-compare -Wunreachable-code -fno-common -dynamic -DNDEBUG -g -fwrapv -O3 -Wall -Wstrict-prototypes -I/usr/local/Cellar/python3/3.5.0/Frameworks/Python.framework/Versions/3.5/include/python3.5m -c greenlet.c -o build/temp.macosx-10.10-x86_64-3.5/greenlet.o
 creating build/lib.macosx-10.10-x86_64-3.5
 clang -bundle -undefined dynamic_lookup build/temp.macosx-10.10-x86_64-3.5/greenlet.o -o build/lib.macosx-10.10-x86_64-3.5/greenlet.cpython-35m-darwin.so
 installing to build/bdist.macosx-10.10-x86_64/wheel
 running install
 running install_lib
 creating build/bdist.macosx-10.10-x86_64
 creating build/bdist.macosx-10.10-x86_64/wheel
 copying build/lib.macosx-10.10-x86_64-3.5/greenlet.cpython-35m-darwin.so -> build/bdist.macosx-10.10-x86_64/wheel
 running install_headers
 creating build/bdist.macosx-10.10-x86_64/wheel/greenlet-0.4.9.data
 creating build/bdist.macosx-10.10-x86_64/wheel/greenlet-0.4.9.data/headers
 copying greenlet.h -> build/bdist.macosx-10.10-x86_64/wheel/greenlet-0.4.9.data/headers
 running install_egg_info
 running egg_info
 creating greenlet.egg-info
 writing top-level names to greenlet.egg-info/top_level.txt
 writing greenlet.egg-info/PKG-INFO
 writing dependency_links to greenlet.egg-info/dependency_links.txt
 writing manifest file 'greenlet.egg-info/SOURCES.txt'
 warning: manifest_maker: standard file '-c' not found
 reading manifest file 'greenlet.egg-info/SOURCES.txt'
 reading manifest template 'MANIFEST.in'
 writing manifest file 'greenlet.egg-info/SOURCES.txt'
 Copying greenlet.egg-info to build/bdist.macosx-10.10-x86_64/wheel/greenlet-0.4.9-py3.5.egg-info
 running install_scripts
 Traceback (most recent call last):
 File "<string>", line 1, in <module>
 File "/private/var/folders/xk/8lhz2_j91_3758cc65stj5z40000gn/T/pip-build-sxtdlufe/greenlet/setup.py", line 101, in <module>
 **setuptools_args)
 File "/usr/local/Cellar/python3/3.5.0/Frameworks/Python.framework/Versions/3.5/lib/python3.5/distutils/core.py", line 148, in setup
 dist.run_commands()
 File "/usr/local/Cellar/python3/3.5.0/Frameworks/Python.framework/Versions/3.5/lib/python3.5/distutils/dist.py", line 955, in run_commands
 self.run_command(cmd)
 File "/usr/local/Cellar/python3/3.5.0/Frameworks/Python.framework/Versions/3.5/lib/python3.5/distutils/dist.py", line 974, in run_command
 cmd_obj.run()
 File "/private/tmp/venv_bug/lib/python3.5/site-packages/wheel/bdist_wheel.py", line 213, in run
 archive_basename = self.get_archive_basename()
 File "/private/tmp/venv_bug/lib/python3.5/site-packages/wheel/bdist_wheel.py", line 161, in get_archive_basename
 impl_tag, abi_tag, plat_tag = self.get_tag()
 File "/private/tmp/venv_bug/lib/python3.5/site-packages/wheel/bdist_wheel.py", line 155, in get_tag
 assert tag == supported_tags[0]
 AssertionError
 ----------------------------------------
 Failed building wheel for greenlet
Failed to build greenlet
Installing collected packages: greenlet
 Running setup.py install for greenlet
Successfully installed greenlet-0.4.9
3. Install uWSGI
(venv_bug)$ /tmp CFLAGS="-I/tmp/venv_bug/include/python3.5m" UWSGI_PROFILE="asyncio" pip install uwsgi
Collecting uwsgi
 Using cached uwsgi-2.0.11.2.tar.gz
Building wheels for collected packages: uwsgi
 Running setup.py bdist_wheel for uwsgi
 Complete output from command /private/tmp/venv_bug/bin/python3.5 -c "import setuptools;__file__='/private/var/folders/xk/8lhz2_j91_3758cc65stj5z40000gn/T/pip-build-bru7wwac/uwsgi/setup.py';exec(compile(open(__file__).read().replace('\r\n', '\n'), __file__, 'exec'))" bdist_wheel -d /var/folders/xk/8lhz2_j91_3758cc65stj5z40000gn/T/tmpwoq08qywpip-wheel-:
 running bdist_wheel
 running build
 running build_py
 creating build
 creating build/lib
 copying uwsgidecorators.py -> build/lib
 installing to build/bdist.macosx-10.10-x86_64/wheel
 running install
 plugins/greenlet/greenlet.c:2:10: fatal error: 'greenlet/greenlet.h' file not found
 #include <greenlet/greenlet.h>
 ^
 1 error generated.
 ----------------------------------------
 Failed building wheel for uwsgi
Failed to build uwsgi
Installing collected packages: uwsgi
 Running setup.py install for uwsgi
 Complete output from command /private/tmp/venv_bug/bin/python3.5 -c "import setuptools, tokenize;__file__='/private/var/folders/xk/8lhz2_j91_3758cc65stj5z40000gn/T/pip-build-bru7wwac/uwsgi/setup.py';exec(compile(getattr(tokenize, 'open', open)(__file__).read().replace('\r\n', '\n'), __file__, 'exec'))" install --record /var/folders/xk/8lhz2_j91_3758cc65stj5z40000gn/T/pip-69gibzr6-record/install-record.txt --single-version-externally-managed --compile --install-headers /private/tmp/venv_bug/bin/../include/site/python3.5/uwsgi:
 running install
 plugins/greenlet/greenlet.c:2:10: fatal error: 'greenlet/greenlet.h' file not found
 #include <greenlet/greenlet.h>
 ^
 1 error generated.
 ----------------------------------------
Command "/private/tmp/venv_bug/bin/python3.5 -c "import setuptools, tokenize;__file__='/private/var/folders/xk/8lhz2_j91_3758cc65stj5z40000gn/T/pip-build-bru7wwac/uwsgi/setup.py';exec(compile(getattr(tokenize, 'open', open)(__file__).read().replace('\r\n', '\n'), __file__, 'exec'))" install --record /var/folders/xk/8lhz2_j91_3758cc65stj5z40000gn/T/pip-69gibzr6-record/install-record.txt --single-version-externally-managed --compile --install-headers /private/tmp/venv_bug/bin/../include/site/python3.5/uwsgi" failed with error code 1 in /private/var/folders/xk/8lhz2_j91_3758cc65stj5z40000gn/T/pip-build-bru7wwac/uwsgi
Also setuptools is at latest version 18.2.
Installing uwsgi site wide succeeds. greenlet directory is present inside `python3.5m`.
(venv_bug)$ /tmp ls -la /usr/local/include/python3.5m | grep greenlet
drwxr-xr-x 3 root admin 102 Nov 1 20:40 greenlet
Links:
uWSGI asyncio: https://uwsgi-docs.readthedocs.org/en/latest/asyncio.html#building-uwsgi-with-asyncio-support
Greenlet issue thread: https://github.com/python-greenlet/greenlet/issues/96