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We could add a flag memoryview(x, raw=True) to the constructor. This view 
would behave exactly like the regular one except that it ignores buf.format 
entirely.
So you could do assignments like:
 m[10] = b'\x00\x00\x00\x01'
This would be more flexible in general since memoryview currently only supports
native struct formats (complex formats slow down certain operations dramatically).
I think the feature would not add much additional complexity to the code.
The question is: Is this a general need? Are many people are using memoryviews
for bit-twiddling?