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I believe this is mostly a curiousity (since actually calculating a factorial this big would take an interminable amount of time), but math.factorial can be provoked into throwing OverflowError by a large enough input:
>>> math.factorial(10**19)
Traceback (most recent call last):
 File "<stdin>", line 1, in <module>
OverflowError: Python int too large to convert to C long
>>> math.factorial(1e19)
Traceback (most recent call last):
 File "<stdin>", line 1, in <module>
OverflowError: Python int too large to convert to C long