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Here is a patch which speed up compiling of regular expressions with big charsets.
Microbenchmark:
$ ./python -m timeit "from sre_compile import compile; r = '[%s]' % ''.join(map(chr, range(256, 2**16, 255)))" "compile(r, 0)"
Unpatched (but with fixed issue19327): 119 msec per loop
Patched: 59.6 msec per loop
Compiling regular expressions with big charset was main cause of slowing down importing the email.message module (issue11454).