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I also just tried using os.listdir() for a package before searching for __init__ and it didn't speed anything up either (actually timeit suggests that os.listdir() is worse than an isdir + 3 * isfile checks). Nor did caching directory stuff at the class level so that they were shared when an os.listdir() was done for an __init__ so that didn't have to be done a second time if the cache wasn't stale already.
I have attached the patch with all of the changes to cut the number of stat calls down significantly, but benchmarking on my work machine shows no definitive benefit.