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IMHO it's very much dependent on the change. When making C code changes, I usually run the relevant tests with refleaks, and then run the whole test suite; all of this --with-pydebug. Personally I've not encountered cases where non-debug builds failed where debug suceeded for CPython, but for very significant changes I may do some extra runs in the release mode as well (or try to test it on a specific OS). It's very important to watch the bots after committing, because they run a wide variety of configurations you'll be hard pressed to reproduce on your own - so they exercise the change pretty well.