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Let me throw in a quick reminder that Cython has substantially faster argument parsing than the C-API functions provide because it translates function signatures like
 def func(int a, b=1, *, list c, d=2):
 ...
into tightly specialised unpacking code, while keeping it as compatible as possible with the equivalent Python function (better than manually implemented C functions, BTW). Might be an alternative to the Argument Clinic, one that has been working for a couple of years now and has already proven its applicability to a large body of real world code.