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Serialize/deserialize md5 context. Pseudocode:
import md5
# Start hash generation
m = md5.new()
m.update("Content")
# Serialize m
serialized_m = serialize(m)
# In another function/machine, deserialize m
# and continue hash generation
m2 = deserialize(serialized_m)
m2.update("More content")
m2.digest() 
There are C++ lib but no Python one.