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Occasionally, the isclosed() method of HTTPResponse instances returns False, even though a preceding read() call returned '' (or something else that evalues to False).
This is a problem, because then the corresponding HTTPConnection can still be used to send another request, but an attempt to retrieve its response result it in ResponseNotReady() exception.
I have not found anything special about the requests for which this happens. I also looked at the httplib code and found no way for this to happen, but obviously I am missing something. Maybe someone more familiar with the codebase can tell what's happening there.
The problem happens to rarely to be able to run packet capture, but I can provide attributes of the relevant httplib instances if desired.