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On Windows I can't use a source build of Python to create a venv which will compile C extensions because pyconfig.h cannot be found. For example
 running build
 running build_ext
 building 'demo' extension
 creating build
 creating build\temp.win32-3.3
 creating build\temp.win32-3.3\Release
 c:\Program Files (x86)\Microsoft Visual Studio 10.0\VC\BIN\cl.exe /c /nologo /Ox /MD /W3 /GS- /DNDEBUG -IC:\Repos\cpython\include -IC:\Users\oudkerk\myenv\PC /Tcdemo.c /Fobuild\temp.win32-3.3\Release\demo.obj
demo.c
 C:\Repos\cpython\include\Python.h(8) : fatal error C1083: Cannot open include file: 'pyconfig.h': No such file or directory
 error: command '"c:\Program Files (x86)\Microsoft Visual Studio 10.0\VC\BIN\cl.exe"' failed with exit status 2
The problem seems to be with the following line in distutils/command/build_ext.py:
 self.include_dirs.append(os.path.join(sys.exec_prefix, 'PC'))
Inside a venv, sys.exec_prefix is the venv directory.