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Some review comments. Instead of doing the inline unquote like this -
- auth = base64.b64encode(user_passwd).strip()
+ auth = base64.b64encode(unquote(user_passwd)).strip()
It is better to do the explicitly above the b64 encoding step.
Just as host has been unquoted.
 user_passwd, host = splituser(host)
 host = unquote(host)
Also, you have done this only for https_open, the same would need be replicated for http_open and also for proxy_passwd. Also on tests, Modifying sendall with
 def sendall(self, str):
- pass
+ FakeHTTPConnection.request += str
seems a bit odd to me, you are using a class level object and adding a str. I think, there should be better way to do. (I shall provide an example). Also str term can replaced, even if it was coming from old code.