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There are a number of places in packaging.install where temporary directories are created, but never cleaned up:
1. In _move_files, if no destination path is passed in, one is created using mkdtemp(), but it's not clear where this would be deleted. Moreover, it's never called without a path and not part of the public API, so it would make sense to always expect a destination to be passed in (and update the docstring to match)
2. install_local_project, in the case of an archive, unpacks it into a mkdtemp()'d directory, but never deletes that directory later.
3. install_dists() also calls mkdtemp() if a path is not passed in, but it's not clear where this would be deleted. This should be changed to always require a path to be passed in. The install_from_infos accepts None as an install path and passes that to install_dists, but why are we being so generous? It's not asking a lot to be given an explicit path to install to.
Note: the DistInfo class in packaging.pypi.dist also does this kind of thing (in the download and unpack methods) - it would seem sensible to make similar changes there.