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There is a 'reinitialize_command' function in setuptools' command class which can initialize a command with a key-value pair, but it seems that distutils2/packaging does not yet have this function. I think it's useful in the condition that we want to run some commands with some options initialized. 
For instance, if we want to run 'build_ext' command with its 'inplace' option initialized, we can use : self.reinitialize_command('build_ext', inplace=1), and then self.run_command('build_ext') .