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Extract of manpage signal(7):
"The following interfaces are never restarted after being interrupted by a signal handler, regardless of the use of SA_RESTART; they always fail with the error EINTR when interrupted by a signal handler:
 * ...
 * File descriptor multiplexing interfaces: epoll_wait(2), epoll_pwait(2), poll(2), ppoll(2), select(2), and pselect(2)."
Consider siginterrupt(signal, False) as a "best-effort" trick... which doesn't work with select().
If you don't want select() to be interrupted by SIGINT, use:
pthread_sigmask(SIG_BLOCK, [SIGINT]);
select(...)
pthread_sigmask(SIG_UNBLOCK, [SIGINT])
or
pselect(...., [SIGINT])
pselect() is atomic, whereas pthread_sigmask+select is not.
I added recently pthread_sigmask() to the signal module in Python 3.3.
pselect() is not exposed in Python currently. We may add it if it's needed.
--
If you really don't care of SIGINT, you can also ignore it completly using signal(SIGINT, SIG_IGN).