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I don't know if it's related, but SimpleXMLRPCServer in Python 2.7 uses fcntl(self.fileno(), fcntl.F_SETFD, flags):
class SimpleXMLRPCServer(SocketServer.TCPServer,
 SimpleXMLRPCDispatcher):
 ...
 def __init__(self, ...):
 ...
 # [Bug #1222790] If possible, set close-on-exec flag; if a
 # method spawns a subprocess, the subprocess shouldn't have
 # the listening socket open.
 if fcntl is not None and hasattr(fcntl, 'FD_CLOEXEC'):
 flags = fcntl.fcntl(self.fileno(), fcntl.F_GETFD)
 flags |= fcntl.FD_CLOEXEC
 fcntl.fcntl(self.fileno(), fcntl.F_SETFD, flags)
=> see also issue #1222790.