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With: Python 3.6.1 (v3.6.1:69c0db5, Mar 21 2017, 17:54:52) [MSC v.1900 32 bit (Intel)] on win32
import datetime;
d_Time = datetime.datetime.strptime('03:30 PM', '%I:%M %p');
d_Time = d_Time.astimezone(datetime.timezone.utc);
# RESULTS IN OSError: [Errno 22] Invalid argument
# WHEREAS the foll. does not have the issue!
d_Time = datetime.datetime(year = d_Time.year,
 month = d_Time.month,
 day = d_Time.day,
 hour = d_Time.hour,
 minute = d_Time.minute,
 second = d_Time.second,
 tzinfo = datetime.timezone.utc);
print(d_Time);

on macOS 10.14.4, I got `ValueError: offset must be a timedelta representing a whole number of minutes, not datetime.timedelta(0, 29143).` I will do some research to see why this happen.

This seems like a duplicate (or at least very similar) to the issue 29097. Could you try a newer version of Python (that issue was fixed in 3.6.7) to make sure it's not a duplicate?
That was specifically a Windows bug, Windson, make sure that what you're seeing is not fixed elsewhere if you only have macOS available.

Thanks, SilentGhost, you are right. I will leave this to a Windows expert instead.

I'm going to close this issue as a duplicate of #29097. If you're still experience this problem on python3.7, please re-open.

Encountered this bug on Python 3.7.6 (default, Jan 8 2020, 20:23:39) [MSC v.1916 64 bit (AMD64)], so on Windows 10. I can reproduce the bug with the code in message https://bugs.python.org/msg341149. 
It does not seem to be a duplicate of #29097 since I cannot reproduce that issue.

Yes, I was also able to verify this issue on 3.8.2 on win10. Argument to astimezone is not required, and this happens for both naïve and aware objects.

I'd like to take on this issue if no one else is working on it.

This exception is raised because astimezone() ends up calling time.localtime() to determine the appropriate time zone. If the datetime object has a pre-epoch value, it passes a negative timestamp to time.localtime(). On Windows, time.localtime() does not accept values greater than 0 (more discussion in issue #35796).
This is the minimal code required to reproduce the error:
from datetime import datetime
datetime(1969, 1, 1).astimezone()
Without the ability to ascertain the time zone with localtime(), I'm not sure if the time zone can be accurately determined. It's not clear what the proper behavior is. Maybe raise a ValueError?
PEP 615 proposes to include the IANA tz database, which would negate the need for a system call. Should we wait for this PEP before fixing this issue? Thoughts?

It would be helpful to have a better error message than '[Errno 22] Invalid argument' on Windows, so a ValueError seems to be a good idea at the moment.