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Hi,
I compiled Python 3.7 using PGO+LTO with "make && make install", but it seems like it lacks the _sysconfigdata module.
Moreover, I don't see any "Makefile" file in the installed directory, so the "~/installed/3.7/bin/python3 -S -m sysconfig --generate-posix-vars" command fails on trying to import _sysconfigdata_m_linux_x86_64-linux-gnu ... 
$ find /home/haypo/installed/3.7 -name "Makefile"
<nothing>
Is it correct to use "make && make install" using PGO?
cd ~/cpython
make distclean ||:
./configure --enable-optimizations --with-lto --prefix=/home/haypo/installed/3.7
make clean
make
make install
haypo@speed-python$ ~/installed/3.7/bin/python3 
Failed to import the site module
Traceback (most recent call last):
 File "/home/haypo/installed/3.7/lib/python3.7/site.py", line 544, in <module>
 main()
 File "/home/haypo/installed/3.7/lib/python3.7/site.py", line 530, in main
 known_paths = addusersitepackages(known_paths)
 File "/home/haypo/installed/3.7/lib/python3.7/site.py", line 282, in addusersitepackages
 user_site = getusersitepackages()
 File "/home/haypo/installed/3.7/lib/python3.7/site.py", line 258, in getusersitepackages
 user_base = getuserbase() # this will also set USER_BASE
 File "/home/haypo/installed/3.7/lib/python3.7/site.py", line 248, in getuserbase
 USER_BASE = get_config_var('userbase')
 File "/home/haypo/installed/3.7/lib/python3.7/sysconfig.py", line 601, in get_config_var
 return get_config_vars().get(name)
 File "/home/haypo/installed/3.7/lib/python3.7/sysconfig.py", line 550, in get_config_vars
 _init_posix(_CONFIG_VARS)
 File "/home/haypo/installed/3.7/lib/python3.7/sysconfig.py", line 421, in _init_posix
 _temp = __import__(name, globals(), locals(), ['build_time_vars'], 0)
ModuleNotFoundError: No module named '_sysconfigdata_m_linux_x86_64-linux-gnu'

PGO compilation uses "make profile-removal", maybe my issue is linked to that?
I'm sure that PGO compilation + "make install" worked two months, but using: make profile-opt && make install.

The --enable-optimizations option of ./configure was added by the issue #26359 (first named --with-optimizations, it was recalled to --enable-optimizations later).
See also:
* issue #28032: "never imply --with-lto as part of --with-optimizations"
* issue #28605: Fix the help and What's New entry for --with-optimizations

Ok, I confirm that it's possible to compile and install Python using PGO+LTO without --enable-optimizatioins:
cd ~/cpython
make distclean ||:
./configure --with-lto --prefix=/home/haypo/installed/3.7
make clean
make profile-opt
make install

Ok, I tested again: in fact, "it works" but "make install" recompiles Python from scratch (1st build with -fprofile-generate, profile task, 2nd build with -fprofile-use) whereas "make" just succeeded to build Python!?

Oh, it's just a duplicate of issue #29243.