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The bug can be reproduced by running the following command to create a Windows installer for the attached module:
python setup.py bdist_wininst --install-script pis.py
I include also the installer that I have created in the dist folder.
The installer installs everything correctly and it runs the pis.py script, which simply creates a file in the USERPROFILE directory with the "Installing" string. However, when uninstalling the program from the Windows Control Panel the script is not called, what can be verified by checking that the "Uninstalling" string is not appended to the file.
I am experiencing this problem in Windows 7 64 bits, but it may be present in other platforms.

Sorry, I opened issue13509 after somehow not finding this one. Here is my text from issue13509. Thanks for looking at this problem...
Historically (i.e. Python 2.6.1 and earlier) bdist_wininst would run the post install script at both installation and uninstallation. The script would be invoked with a -install argument on installation and a -remove argument on uninstallation. This stopped working in Python 2.6.2 and has not worked since.
This regression appears to have been introduced in r69094. That checkin rewrote Run_RemoveScript and associated functions in PC/bdist_wininst/install.c. The rewrite changed how the Python DLL was loaded during the remove scenario.
Previously Run_RemoveScript itself called Win32 LoadLibrary on the DLL name parsed from the wininst log file. Now Run_RemoveScript calls run_installscript instead, which ultimately calls LoadPythonDll, which calls LoadLibrary on the pythondll global variable. But nothing initializes that variable during the remove scenario and LoadLibrary fails. Ultimately run_installscript silently fails and the removal proceeds to uninstall files and registry keys, with no notification to the user that the post install script was not run.
A possible solution is to initialize pythondll in Run_RemoveScript to the DLL name parsed from the wininst log file, e.g. by inserting the following code prior to the call to run_installscript:
 strncpy(pythondll, dllname, scriptname - 1 - dllname);
 pythondll[scriptname - 1 - dllname] = '0円';
I tested this and it seemed to work fine.
I believe this problem affects all Python releases following and including 2.6.2. The version history seems to show that r69094 was propagated to all of those releases. Presumably nobody found it because post install scripts on removal are not widely used. They are, however, critical for my application (at least if I want it to clean up properly on removal) so I would appreciate this being fixed. As it stands, I have to build a private patched copy of wininst-9.0.exe to work around this problem.

(2.6 and 3.1 don’t get bug fixes anymore.)

How can I help to ensure that the patch submitted by Jason Roberts is actually taken into account in next releases of Python?
I too would want to use this "remove" feature in distutils Windows installers. For example, I was confronted to this bug/limitation of current releases of Python when implementing this feature for the Spyder Windows installer:
https://code.google.com/p/spyderlib/issues/detail?id=971#c10
Thanks for taking time to fix this issue.

I can confirm that the approach suggested in msg148674 resolves this issue for Python 2.7.3 (32-bit Python running on 64-bit Windows 7). For a standard 2.7.3 install, simply replacing wininst-9.0.exe in the command sub-directory of distutils with the patched build of that executable resolved the issue.

@Pierre.Raybaut: Looking at the stage of this ticker, I believe you need to write unittest. Then attach a patch. If patch is attached, the issue is more visible among developers.

Here is workaround, which is - patching distutils - https://code.google.com/p/spyderlib/wiki/PatchingDistutils 

I believe that this bug—which I reported in 2011—is not correctly tagged, what may explain why it has not been fixed yet. Despite the fact that the original issue report contains a script to reproduce the bug and that msg148674 contains a patch to fix the issue the State of this issue is "test needed". Shouldn't State be "patch review" instead?

The distutils bdist_wininst command has been removed in Python 3.10: see bpo-42802.