diff --git a/Lib/packaging/install.py b/Lib/packaging/install.py
--- a/Lib/packaging/install.py
+++ b/Lib/packaging/install.py
@@ -492,6 +492,12 @@
 purelib_path = get_path('purelib')
 # trying to write a file there
 try:
+ if not os.path.exists(purelib_path):
+ message = """The installation path {} seems not to exist.
+This likely implies that you are trying to install a 3rd-party package
+without a working Python installation. That is unsupported."""
+ logger.info(message.format(purelib_path))
+ return False
 with tempfile.NamedTemporaryFile(suffix=project,
 dir=purelib_path) as testfile:
 testfile.write(b'test')
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