spillR

This is the development version of spillR; for the stable release version, see spillR.

Spillover Compensation in Mass Cytometry Data

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DOI: 10.18129/B9.bioc.spillR

Bioconductor version: Development (3.23)

Channel interference in mass cytometry can cause spillover and may result in miscounting of protein markers. We develop a nonparametric finite mixture model and use the mixture components to estimate the probability of spillover. We implement our method using expectation-maximization to fit the mixture model.

Author: Marco Guazzini [aut, cre] ORCID iD ORCID: 0009-0007-8111-5772 , Alexander G. Reisach [aut] ORCID iD ORCID: 0009-0003-5057-6278 , Sebastian Weichwald [aut] ORCID iD ORCID: 0000-0003-0169-7244 , Christof Seiler [aut] ORCID iD ORCID: 0000-0001-8802-3642

Maintainer: Marco Guazzini <m.guazzini at student.maastrichtuniversity.nl>

Citation (from within R, enter citation("spillR")):

Installation

To install this package, start R (version "4.6") and enter:


if (!require("BiocManager", quietly = TRUE))
 install.packages("BiocManager")
# The following initializes usage of Bioc devel
BiocManager::install(version='devel')
BiocManager::install("spillR")

For older versions of R, please refer to the appropriate Bioconductor release.