SPIA

Signaling Pathway Impact Analysis (SPIA) using combined evidence of pathway over-representation and unusual signaling perturbations

Bioconductor version: 2.7

This package implements the Signaling Pathway Impact Analysis (SPIA) which uses the information form a list of differentially expressed genes and their log fold changes together with signaling pathways topology, in order to identify the pathways most relevant to the condition under the study.

Author: Adi Laurentiu Tarca <atarca at med.wayne.edu>, Purvesh Kathri <purvesh at cs.wayne.edu> and Sorin Draghici <sorin at wayne.edu>

Maintainer: Adi Laurentiu Tarca <atarca at med.wayne.edu>

To install this package, start R and enter:

 source("http://bioconductor.org/biocLite.R")
 biocLite("SPIA")

To cite this package in a publication, start R and enter:

 citation("SPIA")

Documentation

PDF R Script SPIA
PDF Reference Manual

Details

Depends R (>= 2.8.0), graphics
Imports graphics
System Requirements
License GPL (>= 2)
Depends On Me
Imports Me
Suggests Me KEGGgraph
Version 1.8.0
Since Bioconductor 2.4 (R-2.9)

Package Downloads

Package Source SPIA_1.8.0.tar.gz
Windows Binary SPIA_1.8.0.zip (32- & 64-bit)
MacOS 10.5 (Leopard) binary SPIA_1.8.0.tgz

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