In general, particles are classified as
subvisible up to a size of 100 micron.
Overlooking
subvisible particles in therapeutic protein products: gaps that may compromise product quality.
With regards to providing solutions to existing problems, industry still has a lot of room to improve including lowering visible and
subvisible particulates, controlling and/or eliminating silicone oil and providing viable solutions for the growing compounding pharmacy market."
At the same time, there remains a thread of interest in the "
subvisible" or "hidden" nature of form, even if that "hidden" nature is often resolutely de-idealized.
Long term safety, high-resolution imaging, and tissue temperature modeling of
subvisible diode micropulse photocoagulation for retinovascuclar macular edema.
(2015) showed that the frequency of
subvisible cirrus (SVC) in south India has increased by 9% from 1998 to 2013, with possible connections with the positive trend in ATAL's AOD since the late 1990s (Vernier et al.
Wang et al., "
Subvisible retinal laser therapy: titration algorithm and tissue response," Retina, vol.
Schoeberl, "On the formation and persistence of
subvisible cirrus clouds near the tropical tropopause," Journal of Geophysical Research Atmospheres, vol.
Issues with glass delamination and the generation of both visible and
subvisible flakes and particulates in marketed drug products have increased significantly within the last several years, leading to numerous recalls.
Examples include counting and sizing of
subvisible particulate matter per USP Chapter (788) [4] or per European Pharmacopoeia 2.9.19 [5] and measuring the concentrations of larger sized globules in nutritional emulsions per USP Chapter (729) [6].