sirtuin


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sir·tu·in

(sûr′to͞o-ĭn, -tyo͞o-)
n.
Any of a family of enzymes that occur in all living organisms and are thought to regulate cellular aging, apoptosis, and resistance to stress in more complex eukaryotic organisms.
[Alteration of Sir2, name of the first gene coding for the synthesis of such enzymes to be isolated (short for s(ilent mating-type) i(nformation) r(egulation) 2, so called because the gene silences the expression of genes relating to the two mating types of the yeast from which it was isolated ) + -in.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

sirtuin

(sɜːˈtuːɪn)
n
a protein that regulates cell metabolism and ageing
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes.
Mitochondria: overlooking these small organelles can have huge clinical consequences in treating virtually every disease
Proteins known as sirtuins are necessary to achieve this life span extension, with sirtuin 1, or SIRT1, often regarded as the most important.
Trial supplement is no elixir of life: compound lets mice live healthier but not longer lives
28 ( ANI ): A new study has found that activating a protein called sirtuin 1 extends lifespan, delays the onset of age-related metabolic diseases, and improves general health in mice.
Soon, pill that could help you live longer
We used sirtinol, a specific and direct inhibitor of the sirtuin class of deacetylase activity, to inhibit Sirt1 in H1299 cells [30].
The antiproliferative and apoptotic effects of sirtinol, a sirtuin inhibitor on human lung cancer cells by modulating Akt/[beta]-catenin-FoxO3a axis
Fischer et al., "A molecular mechanism for direct sirtuin activation by resveratrol," PLoS ONE, vol.
Leucine modulates mitochondrial biogenesis and SIRT1-AMPK signaling in C2C12 myotubes
Our study proves that metformin does indeed have a direct protective action on the vasculature." Experiments on cultivated mouse cells in the laboratory confirmed that metformin has a direct effect on the vascular function through interaction with a protein called sirtuin 1, which is encoded by the SIRT1 gene, known to play a role in ageing.
WCMC-Q research study published in UK journal
Detractors had claimed Sinclair's data were influenced by a fluorescent chemical--one that doesn't occur in nature--that he used to measure the activation of sirtuin proteins by resveratrol-like compounds.
Scientists shed light on how resveratrol works
Silent Mating Type Information Regulation 2 Homolog 1 (SIRT1) is the most studied member of the sirtuin family.
SIRT1: Importance of O-GlcNAc and Phosphorylation Interplay in Aging and Diabetes
Within this group are Sirtuin proteins, of which seven isoforms (SIRT1-7) have so far been identified in humans.
E. coli endotoxin modulates the expression of sirtuin proteins in PBMC in humans
Turn sirtuin on with a glass of wine, knotweed pie or a sirtuin drug (someday) every night.
Rest that rejuvenates: how to have your best slumber party
They're looking over resveratrol and a series of sirtuin activators described by the Sirtris group in Nature.
Discovery: messaging (& massaging): plus: a 720ドル million sinkhole for GSK?