In extreme cases, almost half of all the proteins that were built, used a different
reading frame or code than the expected code.
Maximum-likelihood phylogeny of the concatenated open
reading frame 1 and 2 nucleotide sequences of hare hepatitis E virus (HEV) strain from Germany (black diamond), related strains from rabbits (bold) and humans, and reference Orthohepevirus A strains, as defined by Smith et al.
(BCP = basal core promoter; Pre-C = pre-core; ORF = open
reading frame; PC = pre-core-core; s Ag = surface antigen; nt = nucleotide; aa = amino acid.
PRRSV replication can be significantly suppressed by interrupting formation of the open
reading frame 7 (ORF7) gene and organizing nucleocapsid protein N [12-14].
Upon further investigation, the team found that a tumor-suppressor gene, called alternative
reading frame (ARF), which is normally suppressed in mouse and human iPSCs, remained active in the mole rat iPSCs.
Primers were designed to generate a product of easily sequenced length (around 650 bases) and be within the open
reading frame of each locus greater than 100 base pairs from each end.
An intact LINE-1 sequence measures approximately 6 kb in length and encodes 2 well-recognized proteins, open
reading frame 1 protein (ORF1p) and ORF2p (Fig.
In this paper, we developed an alignment-free tool, named as "Lncident" (LncRNAs identification), to rapidly predict lncRNA and messenger RNA (mRNA) utilizing sequence intrinsic composition features and open
reading frame information based on support vector machine (SVM).
The research also indicated how these non-random results can be harnessed to produce a desired effect, such as a gene knockout or the
reading frame restoration of a disease-causing allele.
Scientists have identified a mutation in a gene called "chromosome 9 open
reading frame 72" or C9ORF72.