The funding will support the further clinical development of SPR206, Spero's intravenous-administered product candidate from its
Potentiator Platform that is being developed as an innovative alternative option to treat MDR Gram-negative bacterial infections.
The results were confirmed by sequencing of the mip- (macrophage infectivity
potentiator) gene from L.
Rheumatoid factor as a
potentiator of anti-citrullinated protein antibodymediated inflammation in rheumatoid arthritis.
A CFTR
potentiator in patients with cystic fibrosis and the G551D mutation.
This evidence supports chitosan as a robust immune
potentiator for mucosal vaccination.
Including the normative dimension of moral responsibility to sustaining life, and the aesthetic dimension of a relationship with nature, however, reveals waste as a cyclogical
potentiator of vitality, thereby identifying potential emancipation and reconciliation of our Lifeworlds in those very forces which simultaneously repress and alienate us.
Bcl-3 induced by IL-22 via STAT3 activation acts as a
potentiator of psoriasis-related gene expression in epidermal keratinocytes.
Studies with monotherapies of either ivacaftor (
potentiator) or lumacaftor (corrector) have shown little success in these patients (68).
The firm's proprietary triple combination includes a novel cystic fibrosis transmembrane conductance regulator amplifier, third generation corrector and
potentiator, called PTI-428, PTI-801 and PTI-808, respectively.
(NYSE: PFE) PF-04958242, a first-in-class, Phase 2b ready AMPA receptor
potentiator for cognitive impairment associated with schizophrenia, the company said.
Conference highlights include how GARDP are facilitating the research and development of new antibiotics, The Pew Charitable Trusts discussing SPARK; a digital platform where researchers can share data, ideas and insights to aid new antibiotic discovery, and how Oppliotech is using a systems biology approach to develop anti-bacterials via a computational network model to help identify
potentiator targets.