In routine investigations her hemoglobin was 9gm% with peripheral blood smear has mild
hypochromia, Her HIV, HbsAg were nonreactive.
Three factors are responsible for the pathogenesis of IDA: a) Impaired Hemoglobin synthesisas the serum iron falls & transferring saturation achieves a critical value of <15%, the iron is so depleted that Hb production is impaired resulting in microcytosis first followed by
hypochromia of red cells.
PBF showed mild
hypochromia, microcytes, and macrocytes.
The characteristic haematological features are microcytosis,
hypochromia, increased Haemoglobin Subunit Alpha 2 (HbA2) level on Hb electrophoresis3,4.
Hemoglobin levels were reduced in 75% (n= 37) with
hypochromia and microcytosis, Total leucocyte count was mildly raised in 6% (n= 3).
Blood smear shows
hypochromia, microcytosis, marked anisocytosis, fragmented and nucleated red cells, polychromasia and occasionally immature leukocytes.
Peripheral blood showed slightly decreased white blood cell count (4x[10.sup.3]/[micro]L), thrombocytopenia (platelet count, 80x[10.sup.3]/[micro]L), mild
hypochromia, some nucleated red blood cells (2 per 100 white blood cells), and occasional abnormal cleaved cells.
One patient had macrocytosis, three patients had overt hypochromic microcytic indices, five had borderline
hypochromia and microcytosis while the remaining one had normocytic normochromic indices.
Clinical value of
hypochromia markers in the detection of latent iron deficiency in nonanemic premenopausal women.
Red cells having MCH 11.0 g/dl), microcytosis was seen in 107 (22.6%) cases while
hypochromia was present in 72 (15.2%) children.
Biomarkers of
hypochromia: The contemporary assessment of iron status and erythropoiesis.
Peripheral smear showed anemia with mild
hypochromia, rouleaux, rare spherocytes, thrombocytopenia, mature white blood cells with toxic neutrophils, and absence of schistocytes.