ezetimibe


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e·zet·i·mibe

(ē′zĕt′ə-mĭb)
n.
A drug, C24H21F2NO3, that inhibits the absorption of cholesterol from the intestine and is used to treat high cholesterol.
[ezet-, alteration of azet(idine), one of its constituents (az(o)- + -et(e), unsaturated heterocyclic compound suffix) + -imibe, cholesterol-lowering drug suffix (perhaps ultimately shortening and alteration of inhibitor).]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
Translations

ezetimibe

n ezetimiba
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
Through the complementary mechanisms of action of inhibition of cholesterol synthesis (bempedoic acid) and inhibition of cholesterol absorption (ezetimibe), the bempedoic acid / ezetimibe combination tablet is a non-statin, orally available, once-daily, LDL-C lowering therapeutic candidate, currently under review by the FDA.
Esperion Announces Inducement Grants Under NASDAQ Listing Rule 5635(4)
Esperion announced positive top-line results from the Phase 2 bempedoic acid / ezetimibe combination tablet study.
Esperion announces results from Phase 2 study of bempedoic acid/ezetimibe combo
Louis, and colleagues assessed the effect of higher-intensity treatment to lower lipid levels (combination ezetimibe and simvastatin) to simvastatin monotherapy among patients with stabilized ACS during a median six years of follow-up.
High-Intensity Lipid Lowering May Aid Very Elderly After ACS; Benefit of simvastatin-ezetimibe combo after acute coronary syndrome greatest for patients ≥75 years
The new guidelines recommend using ezetimibe or a PCSK9 inhibitor if the goal of 70 mg/dL cannot be achieved with a statin alone.
Guidelines are not mandates
The update was undertaken because new evidence has emerged since the publication of the 2013 American Heart Association/American College of Cardiology (AHA/ACC) cholesterol guideline about additional cholesterol-lowering agents including ezetimibe and proprotein convertase sub-tilisin/kexin type 9 (PCSK9) inhibitors.
AHA/ACC updates blood cholesterol management advice
The others evaluated bempedoic acid as add-on therapy to obtain additional lipid lowering in patients already on a maximum-dose statin, and in combination with ezetimibe (Zetia) as a single pill, also in patients on full-dose statin therapy.
Novel agent cut LDL in statin-intolerant patients
For patients at elevated risk of heart attack or stroke, adding ezetimibe (Zetia[R]) to statin therapy can lower LDL an additional 15 to 20 percent.
When Statins Are Not the Answer: There are other medications and methods to help lower cholesterol
[2] Phytosterolaemia responds well to dietary sterol restriction and ezetimibe but poorly to statin treatment.
Severe hypercholesterolaemia with a high risk of atherosclerosis may be precipitated by a high-sterol diet
Adding ezetimibe (Zetia) to statin therapy lowers this risk even further.
Adding a Second Cholesterol-Lowering Agent Reduces the Likelihood of Recurrent Stroke
We have provided an application for computers and smartphones to make the diagnosis of FH based on the Simon Broome Registry criteria, the Dutch Lipid Clinics Network criteria, and the new Canadian FH definition (6) that uses an imputed baseline LDL-C if the patient is on lipid-lowering therapy with either statins and/or ezetimibe. This application can be accessed online (http:// www.circl.ubc.ca/english/web_fh.html) (29).
Imputation of Baseline LDL Cholesterol Concentration in Patients with Familial Hypercholesterolemia on Statins or Ezetimibe
Fortunately, you probably can reach an LDL below 70 mg/dl by using less expensive oral medications, including high-potency statins--atorvastatin (Lipitor[R]) and rosuvastatin (Crestor[R]) are examples--with or without the cholesterol absorption inhibitor ezetimibe (Zetia[R]), a recent study suggests.
Is Your LDL Level Where It Could (or Should) Be?
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