Commonly used chemotherapy agents include
cisplatinum, epirubicin, 5-fluorouracil, and recombinant interferon [alpha]-2b; however, FLC does not respond to chemotherapy as well as classical HCC.
In 1964, Rosenberg [9] discovered that platinum complexes have the ability to inhibit cell division, and
cisplatinum was later confirmed to be the effective chemical.
Muijs et al., "A comparison of carboplatin and paclitaxel with
cisplatinum and 5-fluorouracil in definitive chemoradiation in esophageal cancer patients," Annals of Oncology, vol.
Neoadjuvant
cisplatinum based combination chemotherapy in patients with invasive bladder cancer: a combined analysis of two Nordic studies; Nordic Urothelial Cancer Group.
Nabilone and metoclopramide in the treatment of nausea and vomiting due to
cisplatinum: a double blind study.
Concurrent
cisplatinum and radiation with or without surgery for advanced head and neck cancer.
One can see the presence of both IR bands of copolymer and
cisplatinum at the vicinity of 782, 1290, 2848, and 3271 [cm.sup.-1] of resulting spectrum.
Cvitkovic, "
Cisplatinum ototoxicity," Clinical Toxicology, vol.
Mozzon et al., "
Cisplatinum and transplatinum complexes with benzyliminoether ligands; synthesis, characterization, structure-activity relationships, and in vitro and in vivo antitumor efficacy," Journal of Medicinal Chemistry, vol.