University of Hong Kong (Hong Kong, China) has patented a method for inhibiting Hepatitis B virus (HBV) replication by
RNA molecules.
The discovery and description of
RNA silencing less than a decade ago has spawned a flood of research, revolutionizing the practice of functional genomics and leading to intensive exploration of its potential application to treat numerous diseases.
Membraneless assemblies of positively- and negatively-charged molecules can bring together
RNA molecules in dense liquid droplets, allowing the
RNAs to participate in fundamental chemical reactions.
A similar level of fluorescence intensity was detected in the cDNA prepared from muscle and hepatopancreas
RNAs isolated using method III (Fig.
At least three classes of sRNAs derived from regions mapping around the 5; termini of genes have been described: transcription initiation
RNAs (tiRNAs) [5], transcription start site-associated
RNAs (TSSa-RNAs) [6-8], and promoter-associated small
RNAs (PASRs) [9, 10].
"A significant amount of research is being invested in understanding the complex nature of how various chromatin-associated
RNAs impact gene expression and epigenetic regulation," said Christophe Couturier, senior vice president and head of the EMD Millipore Bioscience Business Area.
20 August 2014 - US recombinant enzymes and related reagents maker New England Biolabs, or NEB, said yesterday it had exclusively licensed the rights to US Genomic Health Inc's (NASDAQ:GHDX) technology for depletion of abundant
RNAs, which is used to conduct sensitive RNA-seq experiments at a reduced cost.
Depending on the duration of preservation and temperature, the TriPure reagent was able to produce
RNAs with different integrities (figures 4 and 5).
The researchers also discovered a signature of changes in expression of other genes that accompanies expression of the repeat-containing
RNAs.
If
RNAs can do important work without making proteins, the definition of a gene needs to be expanded, says Leonard Lipovich, a geneticist at Wayne State University in Detroit.
In a major cancer-research breakthrough, researchers at McGill have discovered that a small segment of a protein that interacts with
RNA can control the normal expression of genes--including those that are active in cancer.