epitope

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Related to Paratope: agretope, Idiotope

ep·i·tope

(ĕp′ĭ-tōp′)
n.
A small molecular region of an antigen that binds to a particular antibody or antigen receptor on a T cell; an antigenic determinant. A single antigen can have multiple epitopes.
[epi- + Greek topos, place, spot.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

epitope

(ˈɛpɪˌtəʊp)
n
(Medicine) the site on an antigen at which a specific antibody becomes attached
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

ep•i•tope

(ˈɛp ɪˌtoʊp)

n.
a site on an antigen at which an antibody can bind, the molecular arrangement of the site determining the specific combining antibody. Also called antigenic determinant .
[1970–75; epi- + -tope < Greek tópos place; compare topo-]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun 1. epitope - the site on the surface of an antigen molecule to which an antibody attaches itself
immunology - the branch of medical science that studies the body's immune system
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
antigen - any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations
épitope
epitopo
References in periodicals archive ?
Two of the star services are antibody-antigen complex modeling and paratope characterization.
Creative Biolabs Serves Antibody-Antigen Complex Analysis Worldwide
If the L-DOPA antigen were specifically bound to the antibody after this pretreatment, it would mask the antibody's paratope, preventing it from generating false-positive binding events to epitopes in the fixed tissue; and we would expect a negative staining result in subsequent fluorescence imaging.
Catecholic Compounds in Ctenophore Colloblast and Nerve Net Proteins Suggest a Structural Role for DOPA-Like Molecules in an Early-Diverging Animal Lineage
Wingfield, "A cell-penetrating antibody fragment against HIV-1 Rev has high antiviral activity: Characterization of the paratope," The Journal of Biological Chemistry, vol.
Antibody-Mediated Therapy against HIV/AIDS: Where Are We Standing Now?
The basis of this method is mutual affinity between antigens (epitope) and antibodies (paratope).
PRIMARY ORAL MUCOSAL MELANOMAS--TWO CASE REPORTS AND COMPREHENSIVE LITERATURE REVIEW
Vauterin et al., "Paratope determination of the antithrombotic antibody 82D6A3 based on the crystal structure of its complex with the von Willebrand factor A3-domain," The Journal of Biological Chemistry, vol.
The Role of von Willebrand Factor in Vascular Inflammation: From Pathogenesis to Targeted Therapy

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