formoterol

The product is a fixed-dose LAMA/LABA combination of the long-acting muscarinic antagonist (LAMA) aclidinium and the long-acting beta agonist (LABA) formoterol, administered via a PRESSAIR multi-dose inhaler.

Formoterol co-administration minimized simvastatin induced myopathy by significantly increasing myofiber size and number.

The Food and Drug Administration approved formoterol fumarate, a long-acting bet[a.sub.2]-agonist (LABA), as a nebulized maintenance treatment for bronchoconstriction in COPD.

"Research in animals has shown that formoterol can stimulate the growth of muscle and the burning of fat," the Daily Telegraph quoted Paul Lee, the study's lead author, as saying.

Dulera combines an inhaled corticosteroid (mometasone furoate) with a long-acting beta2-agonist (formoterol fumarate).

These patents are directed to compositions of "R-formoterol," a specific form of the formoterol molecule, and their use.

Formoterol has an onset of action of fewer than 15 minutes.

``The combination of formoterol, a popular and growing medication, and clickhaler, represents a significant opportunity for the company.''

Currently, three combinations of inhaled corticosteroid plus long-acting beta-agonists are available for the treatment of COPD, but not this particular combination of mometasone furoate with formoterol fumarate administered with a metered-dose inhaler, which is licensed for asthma treatment in the United States under the name Dulera, Dr.

"There's no need to wipe out the black box warnings on salmeterol and formoterol as monotherapy; that's very appropriate.

The Symbicort warning states that an increased risk of asthma-related death with long-acting [[beta].sub.2]-agonists was demonstrated in a large placebo-controlled trial of salmeterol, and that "this finding with salmeterol may apply to formoterol" as well.